| St. Jude Children’s Research Hospital is an academic research institute where investigators conduct cutting-edge research that directly impacts the care our patients receive in the clinic. Current postdoc opportunities are outlined below. Please visit www.stjude.org/postdoc for additional details. Our applicant-friendly process allows multiple faculty to view your CV – simply email your CV to postdoc@stjude.org, refer to this advertisement, and indicate your interest in one or more of these exciting opportunities. Brian Abraham, PhD The Lab of Dr. Brian Abraham builds analytical software pipelines to find answers to biological questions about gene regulation in big datasets, usually from applied sequencing experiments such as ChIP-Seq, RNA-Seq, and Hi-ChIP. The goal is to characterize the core regulatory circuitry driving understudied human cancers. Xiang Chen, PhD A position is available to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations, and to discover potential biomarkers for predicting drug responses in pediatric cancers. Yong Cheng, PhD The Cheng lab aims to accurately identify causal Cis-regulatory module (CRM) variants that affect normal blood cell development and impact childhood blood disorders. Identifying these CRMS will facilitate precision medicine by allowing us to treat genetic diseases by manipulation of CRM function via gene editing or pharmacological approaches. Paul Geeleher, PhD The Geeleher lab has 2 open positions. 1) Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents. 2) Developing statistical methods for integrating single cell and bulk tissue expression data to understand the relationship between common inherited genetic variation, gene expression, and drug response. Jeffery Klco, MD, PhD The Klco lab investigates the mechanisms of disease progression through the molecular characterization of different somatic and germline mutations in pediatric myeloid tumors, as well as the identification of vulnerabilities that may present unique therapeutic options. Kevin Krull, PhD The department of Epidemiology & Cancer Control is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, pharmacology, and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS). Heather Mefford, PhD The Mefford lab is seeking a postdoctoral fellow in translational neuroscience to study genomic and epigenomic causes of pediatric epilepsy and related disorders. Projects include integrated analysis of genome and transcriptome data to identify novel causes of pediatric epilepsy; investigating epigenetic causes of epilepsy; and functional studies of genetic epilepsies using patient-derived stem cell models. Motomi Mori, PhD Positions are available in diverse biostatistics research areas, including designs of early phase clinical trials, epidemic modeling and microsimulation methods, machine learning, analysis of high-dimensional data, integrative omics analysis, survival analysis and longitudinal data. David Rogers, PharmD, PhD The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi (C. auris). Daniel Savic, PhD Dr. Savic studies the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, and resistance and leukemia relapse. The goal is to gain better understanding of the genetic underpinnings of chemotherapeutic drug resistance/relapse in pediatric leukemia. Jun Yang, PhD The Yang lab combines computational biology analyses of large genomic datasets with mechanistic studies using in vitro and in vivo model systems to dissect the cellular and molecular pathways underlying leukemogenesis and leukemia drug response. Jiyang Yu, PhD The candidate will be jointly trained in the labs of Drs. Jiyang Yu and Jun J. Yang and will perform integrative analysis of multidimensional datasets at the bulk and single-cell levels, including whole genome/exome sequencing, bulk and single-cell RNA-seq/ATAC-seq, proteomics, and ex vivo drug sensitivity profiling of preclinical and clinical leukemia samples. Jinghui Zhang, PhD The Zhang lab is seeking candidates to lead discovery and/or method development of non-coding driver variants that affect gene regulation in the context of predisposition, initiation, and progression of pediatric cancer; clonal evolution of relapsed cancer; and genomic cloud, clinical data integration and visualization. | 
